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According to research, supplementing subjects with 5 mg of folic acid and 250 mg of vitamin B12 for 12 weeks reduced plasma homocysteine levels by 32% in subjects with coronary artery disease [55]

doi: 10.1016/j.foodchem.2014.12.015

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and the results were expressed in relative luminescence units

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They concluded that neck texture exhibits both greater sensitivity and specificity than neck pigment for AN detection, because visible roughness of the neck is recognizable without touching or disrobing patient, affording an instant assessment of AN