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Individuals facing chronic stress or hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis, such as in generalized anxiety, may also benefit from DSIPs modulatory effects

The 8 mg dose subgroup had an MD of 28.51 (95% CI: 60.58 to 3.56, P = 0.08), with significant heterogeneity ( P = 0.0003, I 2 = 92%)

Nat Commun (2019) 10(1):111

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Emerging targets of disease-modifying therapy for systemic sclerosis