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Early in the disease course, ferroptotic processes may be subtle and localized, potentially yielding false-negative results

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noting that there was overt SMC pathology in these genetic models

These cumulative effects suggest Pb impairs GABAergic homeostasis by interfering with GABA synthesis, transport, and receptor function, contributing to excitatory/inhibitory imbalance and neurobehavioral deficits

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Additional information DISCLOSURE/CONFLICT OF INTEREST Michael Berk declares that over the past three years, he has received compensation from Stanley Medical Research Foundation, MBF, NHMRC, Beyond Blue, Geelong Medical Research Foundation, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Organon, Norvatis, Mayne Pharma and Servier