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Statements Data availability statement The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher

Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

This has a laxative effect, which helps digested food move through your gut more smoothly

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doi: 10.1172/JCI22217

Additional pre-clinical [251, 252] and clinical [253, 254] work by Kuiper and colleagues confirmed this inverse relationship between HIF-1 activity and tumor ascorbate levels