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However, long-term use of high concentrations, large-area topical applications, or injectable administration may increase the potential risk of copper accumulation in skin tissues

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Y., Wang, S

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Rinner O., Mueller L.N., Hublek M., Mller M., Gstaiger M., Aebersold R

This occurs because solid tumors generally exist in hypoxic conditions, marked by diminished oxygen and glucose levels, creating a conducive environment for CSCs to endure and evade cell death

Key components of ROS-induced proapoptotic cascades including ASK-1, the Bcl-2 associated X-protein (Bax), p53, p38/pJNK/pERK, mTor, Akt, caspase-9, and caspase-3
