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In yeast, Fis1 interacts with the ligand protein Mdv1 to promote the synthesis and assembly of Drp1-GTP oligomers, which are involved in the regulation of mitochondrial asymmetric fission (Stojanovski et al., 2004), where FIS1 is required to interact with additional outer membrane receptors, including Mff, MID49, and MID51, to facilitate Drp1 polymerization and assembly into a helical or ring structure surrounding the mitochondrial outer membrane, thereby recruiting Drp1 to the division site, which ultimately initiates fission (Takamura et al., 2012)

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