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Scientific Background Small-molecule metabolic regulators are widely used in research exploring enzymatic signaling pathways

When an individual has an MTHFR polymorphism, their body struggles to efficiently convert synthetic cyanocobalamin (the cheap form of B12 found in most standard supplements and fortified foods) into the active methylcobalamin required by the cells

Yet another compound, Honokiol (HKL), has been shown to protect against doxorubicin-induced cardiotoxicity by activating SIRT3, which helps reduce ROS production, prevent mitochondrial fragmentation, and promote mitochondrial fusion 187

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