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Based on survey responses from a convenience sample of 69 medical professionals (including physicians, nurses, advanced practitioners, medics, etc.), the smallest clinically meaningful reduction in hangover symptoms that would represent effective treatment using NAC was 69.4% (from a maximum score of 52 to 15.9), requiring a minimum sample size of only 4

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10.1128/AEM.05605-11 170 WangJ.WangL.XuL.ShiY.LiuF.QiH.et al (2017)

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Dietary Glu supplementation increased the plasma concentrations of Glu, aspartate, asparagine, citrulline, arginine, and tyrosine in HSB without LPS challenge but had no effect on those AAs in LPS-challenged fish ( Table 4 )