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The deletion or inactivation of Parkin down-regulates PGC-1, which in turn leads to the selective degeneration of dopamine neurons in the substantia nigra pars compacta (SNpc)

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For the purpose of description of activity the response stimulated by the TH cells is referred to as being of two types, THl and TH2

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Under these conditions, it may help to add a stretch of glycines, or histidine or a flag tag between the TEV cleavage site and the N-terminus of the target protein