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This reversal was seen also on the background of the disturbed prostaglandins- and NO-systems, prostaglandins synthesis inhibition as well as NO-overstimulation (NOS-substrate L-arginine) or NO-blockade (N(G)-nitro-L-arginine methyl ester (L-NAME)) (Stupnisek et al., 2012

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Depletion of intestinal microbiome partially rescues bone loss in sickle cell disease male mice

doi: 10.1136/bjo.2004.049544

Animal studies have indicated that BPC-157 can reduce inflammatory markers and tissue damage associated with various inflammatory conditions