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Chronic stress Long-term stress increases oxidative processes in the body, leading to GSH depletion and reduced ability to neutralize harmful molecules

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Neuropsychopharmacology 34 , 249250 (2009)

Second, the previous observations may reflect the clinical setting where oxymetazoline, a routinely used airway decongestant, shows an excessive ability to cause tachyphylaxis (desensitization) upon prolonged use (Vaidyanathan et al., 2010