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doi: 10.1007/s00415-010-5664-7

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Evening application before bed allows overnight absorption but requires complete drying to avoid pillow transfer

Current evidence supports excellent safety for long-term use with appropriate cycling

In RA, the synovial tissue is the defined by the presence of various pro-inflammatory cytokines, such as TNF-, IL-1, IL-6, IL-12, and IL-23, thus creating an inflammatory microenvironment causing the damage of the joints [188]