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Many candidate compounds (such as curcumin) have poor oral bioavailability, rapid metabolism, formulation-dependent exposure, and uncertain CNS penetration, while plasma pharmacokinetics may not accurately represent drug levels within compartmentalized CNS lesions, especially in progressive disease (Liu et al., 2016

The GSH:GSSG ratio is a rough readout of oxidative stress: A high ratio suggests resilient cells

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Material and methods Construction of plasmids expressing TAT-CcSOD1 fusion protein The TAT-CcSOD1 expression vectors were constructed by incorporating the coding sequences of HIV-1 TAT and CcSOD1 into the pET-24a vector

C., Oliveira, K., Galhano, C., Guerra, M., Ribeiro, M