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However, in the case of afatinib, ERS activation is essential for drug-induced apoptosis in tumor cells

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Hyperactivation of the PI3KAKTmTOR pathway could also result in an imbalance between nuclear-encoded and mitochondrial-encoded subunits of the respiratory complexes, as observed for MYC, leading to the production of misassembled complexes, loss of supercomplexes and increased ROS production through Mechanism B

However, it is not clear at this time whether Protandim has the same effect in people, or whether these potential effects are beneficial

Preventing Ferroptosis A relatively recent discovery in cellular biology is a process called ferroptosis