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Both paracellular hyperpermeability [demonstrated by abnormal TJ expression and upregulation of myosin light chain kinase (MLCK) activity (86, 322324)] and transcellular hyperpermeability [represented by bacterial internalization to epithelia (325)] were documented in mucosal biopsies of patients with Crohn's disease and UC

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Stopping ICI treatment is usually not necessary (Barroso-Sousa et al

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Neither compound has marketing authorisation as a pharmaceutical in any jurisdiction