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A systematic review and meta-analysis of findings from 15 randomized controlled trials with a combined total of 853 male and female participants found DHEA therapy had beneficial effects on depressive symptoms compared with placebo, although a firm conclusion could not be drawn due to the low quality of the evidence

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This discrepancy can partially be explained by gaps in knowledge surrounding the cellular and molecular landscape of ROS in wound healing, including for example, the role of ROS and metabolism 76,127 , as well as that of redox signalling and stem cell homeostasis