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By aligning treatment regimens with endogenous biological rhythms, these interventions may enhance therapeutic efficacy, minimize adverse effects, and allow for more personalized treatment approaches, particularly in patients with comorbid conditions like CKD and eye disorders such as glaucoma, DR, and DED

doi: 10.1080/13550280390200994

doi: 10.1016/j.biomaterials.2025.123280

This result is consistent with a previous study [29] that showed that decreasing NAA correlated with cognitive dysfunction as well as with disability in RRMS patients using 1H-MRS

A 2021 study in Gut found that long COVID patients had significantly reduced microbiome diversity and specific depletions in beneficial species, including Faecalibacterium prausnitzii and Bifidobacterium bacteria known for their anti-inflammatory and immune-regulatory properties

While many healthcare providers acknowledge the potential health impacts of MTHFR mutations, others remain skeptical, especially given the wide range of individual responses to the mutation