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Whats the diagnosis

The intestinal microecological disorder of NAFLD is characterized by the imbalance of flora-intestinal-hepatic axis, and the present study systematically reveals that ginseng can improve the metabolic abnormalities by regulating the homeostasis of intestinal flora in a multi-dimensional way (Figure 5) ( High-fat diets increases intestinal permeability and exposes the liver to endotoxins, and a disturbed gut microbiota also disrupts the intestinal vascular barrier, enhancing intestinal permeability and bacterial lipopolysaccharide leakage into the circulation (Mouries et al., 2019)

Pettegrew and collaborators 35 pointed out that ALCAR is a potentially important biologic acetylating agent which could modify amino-acid and protein dynamics, function, turnover, structure and activity by acetylating NH2 and OH functional groups in amino acids such as lysine, serine, threonine and tyrosine as well as N-terminal amino acids

The study also had a very small patient population, which reduces its external validity

The effect of valproate on testicular development and on sperm parameters and fertility in humans is unknown

Oracz J, Zyzelewicz D, Nebesny E