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All data were analyzed using SAS 9.2 (SAS Institute, Cary, NC, USA)

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This is particularly challenging in the case of eukaryotic genes, which are often interrupted by long stretches of noncoding sequences (introns)

[1] Toxicity is extremely rare, though adverse reactions including hypersensitivity can occur, particularly with injectable forms

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Furthermore, the number of T cells (CD3), B cells (CD19) and macrophages (CD68) was increased in the lamina propria of new-onset treatment-nave RA patients (Fig