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Importantly, these patients do not exhibit severe immunodeficiency ( This unique clinical phenotype strongly supports DPP1 inhibition strategy feasibility, indicating that even with severely reduced NSP activity, overall immune defense function can remain essentially intact

Ferraz-de-Paula V, Ribeiro A, Souza-Queiroz J, Pinheiro ML, Vecina JF, Souza DPM, Quinteiro-Filho WM, Moreau RLM, Queiroz MLS, Palermo-Neto J (2014) 3,4-methylenedioxymethamphetamine (MDMAecstasy) decreases neutrophil activity through the glucocorticoid pathway and impairs host resistance to Listeria monocytogenes infection in mice

doi:10.1021/ja01853a512

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Nature 583 , 459468 (2020)

Angiotensin-converting enzyme inhibition and angiotensin AT(1)-receptor antagonism equally improve doxorubicin-induced cardiotoxicity and nephrotoxicity