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The most well-established among them appears to be nuclear factor erythroid 2-related factor 2 (Nrf2), which is likely activated by redox status changes of the kelch-like ECH associated protein 1 (Keap1) induced by NAPQI

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doi: 10.1080/20002297.2022.2131117

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When youre taking a creative risk like that and youre trying to hit such a very strange, particular tone, theres always the possibility that people will look at it and be like, Why the fuck did you make another show where it features violence