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Glutathione plays an important role in supporting normal immune system function and helping the body manage oxidative stress

However, the possibility of IGF-I to influence neural stem cells (NSC) is still on debate despite the fact that IGF-I and IGF-IR are expressed in cultured NSC[60, 61], and that in response to IGF-I, cultured NSC proceed toward specific lineages, such as neurons[62] or oligodendrocytes[63]

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This process can induce cell apoptosis by regulating the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) pathway, mitogen-activated protein kinases (MAPKs), or protein kinase C (PKC) and autophagy through the promotion of the AMPK/mTORC and JNK-Bcl-2/Beclin 1 pathways [5]

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KD is a high-fat, very low-carbohydrate, and moderate-protein dietary approach that induces ketosis, defined by serum ketone body concentrations exceeding 0.5 mmol/L