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Description
Pre-complexed GHK-Cu delivers a defined copper payload directly to tissues and activates copper-dependent enzymatic pathways including lysyl oxidase (collagen crosslinking) and superoxide dismutase immediately upon cellular uptake

[5] Topical GHK-Cu is generally considered well tolerated, yet therapy should be avoided in individuals with a known hypersensitivity to copper peptides or any vehicle component

While its ability to influence multiple pathways of repair is supported by compelling preclinical data, the absence of high-quality human trials, the FDAs strict regulatory stance, and the risk of contamination from unregulated sources raise serious safety and legal concerns (including malpractice concerns and fines)
Diffusion and Transport of Reactive Species Across Cell Membranes

doi: 10.3389/fendo.2022.861757
Duong, H
