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Comparative studies in obese mice showed that AOD-9604 produced slightly greater fat reduction than the unmodified fragment at equivalent doses

Individual biochemistry, receptor sensitivity, and unknown factors mean some people simply don't respond to GHK-Cu as expected

Insulin Insulin, a major negative regulator of adipocyte lipolysis, binds the insulin receptor (IR) and through the docking protein insulin receptor substrate 1 (IRS1) and IRS2 (116), activates the lipid kinase phosphatidylinositol 3-kinase (PI3-K), increasing production of PIP3 which stimulates the serine threonine kinase AKT/Protein kinase B (117) (Figure 2)

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Both peptides share the same amino acid sequence from human growth hormone (positions 176-191)

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