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It acts through the growth hormone secretagogue receptor (GHS-R1a) to enhance GH pulses

Tesamorelin received FDA approval in 2010 as Egrifta for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy , a metabolic complication of antiretroviral therapy characterised by preferential accumulation of visceral adipose tissue and associated cardiovascular and metabolic risk

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Oxidative mechanisms may also regulate GPx-1 gene transcription via nuclear factor B (NFB) sites and activator protein 1 (AP-1) sites in the promoter

Neuropeptides, 2002

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