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In pancreatic ductal carcinoma cells, suppression of GPx1 expression promoted ROS-induced Akt signaling (measured by Akt phosphorylation) to drive an epithelial-mesenchymal transition that is associated with enhanced tumor growth, whereas overexpression of GPx1 decreased the phenotypic changes in pancreatic ductal carcinoma cells by decreasing ROS-mediated pro-survival signaling in these cells [134]

and Garg et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Denomme M.M., McCallie B.R., Parks J.C., Schoolcraft W.B., Katz-Jaffe M.G

The membranes were prehybridized at 60C for 2 hours, then hybridized at 60C for 10 hours, and washed with wash solution twice for 15 minutes

Z Naturforsch C

It has yet to be determined how such a labile molecule as LTA 4 is transferred from 5-LOX to LTA4H and how the metabolite LTB 4 is transported to the plasma membrane for export, but it is presumed to be protected in a hydrophobic pocket in a protein such as albumin