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Coagulation Abnormalities Methimazole and to a lesser extent propylthiouracil (PTU) inhibit vitamin Kdependent clotting factor activation (-carboxylation) and epoxide reductase (necessary for vitamin K recycling, and the same enzyme targeted by warfarin) at high concentrations

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Drugs that reduce pseudocholinesterase activity: Oral contraceptives MAO inhibitors Chlorpromazine Metoclopramide Additive Effects: Aminoglycoside antibiotics (enhanced neuromuscular blockade) Clinical Summary Figure 3