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Several randomized, controlled clinical trials have shown that this drug is effective in reducing pain and fatigue and improving sleep quality (increased slow-wave sleep duration and decreased night-time awakenings)

Fang H, Kang J and Zhang D

An elevated serum vitamin B12 is best interpreted against the laboratory's own reference ranges and assay context, with attention to the source-sensitive details along the way and escalation to targeted testing or specialty referral reserved for when a clinician-guided pathway supports it

Conclusion: Optimizing Your B12 Therapy Optimizing B12 therapy means looking at the patients health, treatment goals, and how they react to treatment

Freeze rules: do not repeatedly freezethaw a reconstituted solution

International Journal of Cardiology 2013;169:8994