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Another problem is the metabolic instability, poor membrane permeability, and low bioavailability of some Nrf2 modulators, such as curcumin and its analogs

10.1038/srep08952 278 YuL.YangH.ChengF.WuZ.HuangQ.HeX.et al (2021)

Similar results were obtained with mRNA expression of MMP-2 ( P =0.01), stromal-derived factor-1 (SDF-1) ( P =0.01), tumor growth factor (TGF)- ( P =0.001) and poly-(ADP-ribose) polymerase (PARP) that occurs in response to DNA damage ( P =0.001) (Figure 5b)

Sci Rep 14 , 15153 (2024)

10.1016/j.it.2019.02.001 80 NuhuF.GordonA.SturmeyR.SeymourA
