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J Biol Chem 292:638651 Kelly BS, Antholine WE, Griffith OW (2002) Escherichia coli gamma-glutamylcysteine synthetase

Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells

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