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Deficiency in the level of activity of glucose-6-phosphate dehydrogenase (G6PD) is the basis of favism, primaquine (an anti-malarial drug) sensitivity and several other drug-sensitive hemolytic anemias, anemia and jaundice in the newborn, and chronic nonspherocytic hemolytic anemia

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By contrast, chronic cases involving multi-year degeneration, repetitive overuse, failed rehabilitation histories, structural instability, or longstanding inflammatory cycles usually took longer, and the results were inconsistent

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