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Critical role of cavin (Polymerase I and transcript release factor) in caveolae formation and organization

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The consequence of VHL loss of function is constitutively stabilized HIF-1 and HIF-2, a first step in tumor initiation that increases angiogenesis and drives widespread dysregulation of cellular metabolism

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doi: 10.3389/fnsys.2014.00038 25 ArnstenAFLiBM