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Whether or not the interaction observed in this study applies to adults is unknown, but caution should be observed if valproate and aspirin are to be co-administered

doi: 10.1016/j.vph.2018.04.006 84 MaGPanBChenYGuoCZhaoMZhengLet al
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Furthermore, human Apo AI is known to be an effective inducer of endogenous Apo E production from lipid-loaded macrophages and independent of ABCA1-mediated cholesterol efflux, relating to NF-B inhibition and/or PKA pathway activation 115