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In most instances, at least three doses of a test substance are administered or exposed to demonstrate dose dependence

Stiffness and pain give way to smoother movement

Efficacy of mitemcinal, a motilin agonist, on gastrointestinal symptoms in patients with symptoms suggesting diabetic gastropathy: a randomized, multi-center, placebo-controlled trial
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This effect is desirable, and aspirin use in specified doses and intervals is safe

Nature 508 (7495), 258262
