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In subjects with CAD with LDL-C levels well controlled with a statin, the addition of extended release niacin in AIM-HIGH (732) and extended release niacin plus laropiprant (prostaglandin D2 receptor blocker to inhibit flushing) in HPS-2THRIVE (733) failed to reduce cardiovascular outcomes

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The exact reason for this is unclear, but may be because women are more likely to see a doctor about their melanoma at an earlier stage 20

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One major limitation of this study beyond its retrospective design is that patients who received L-carnitine had a significantly different clinical presentation

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