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The metabolites of the gut microbiota may affect the synthesis of neurotransmitters through the tryptophan metabolism pathway and interfere with the brain's regulation of emotions (18)

Indeed, overactivation of PARPs with resulting severe depletion of NAD+ has been highlighted recently by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), which is found to severely deplete cellular NAD+ due to overactivation of PARPs

Although one study by Yi Pu et al

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