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2020;11 doi: 10.3389/fphar.2020.579330
The classical M1 activation phenotype, induced by the presence of IFN-, released by T cells, LPS or DAMP, is characterized by a microglia with the capacity to produce inflammatory cytokines (IL-23, IL-18, IL-12, IL-1, IL-6, TNF-, CCL2, and CXCL10), ROS, NO and matrix metalloproteinases (MMP9 and MMP3), as well as acting as an antigen-presenting cell preventing the entry of pathogens (Cherry et al., 2014
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GABA, an inhibitory neurotransmitter, is biosynthesized by decarboxylation of glutamate (Bu et al., 1992
Enzyme Kinetic Interactions Matrix metalloproteinase (MMP) activity represents a convergent pathway for both compounds
