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During oxidative metabolism and various cellular reactions, mitochondria produce reactive oxygen species (ROS), associated with the function of the mitochondrial electron transport chain

Development 145 , dev146589 (2018)

[DOI] [PubMed] [Google Scholar] 35.Mahmoud E.A., Elgarhy L.H., Hasby E.A., Mohammad L
NAD+ is essential for the function of sirtuins and other metabolic enzymes involved in mitochondrial health and oxidative metabolism

Coplan JD, Mathew SJ, Mao X, Smith ELP, Hof PR, Coplan PM, et al

That progression single, dual, then triple is the simplest way to place retatrutide in context
