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In addition to inducing apoptosis, disulfiram inhibits tumor growth by inducing non-apoptotic cell death, including ferroptosis and cuproptosis
Beier F, Lee RJ, Taylor AC, Pestell RG, LuValle P
Zhang DD
These studies indicate that overproduction of glutathione drives the survival and growth of a small subset of lymphoid tumor cells in 3D gels and xenografts, likely TIC or TIC-like cells, and that glutathione is selectively required for tumor growth in females of a mouse model of lymphoma
Expression of gamma-glutamyltransferase in cancer cells and its significance in drug resistance
