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doi: 10.1111/andr.12850

Beyond pathway inhibition, polyphenols modulate immune responses by influencing macrophage and microglial polarization, shifting from a proinflammatory M1 phenotype to an antiinflammatory M2 state, thereby enhancing the release of antiinflammatory mediators such as IL10 and arginase1 (Di Meo et al

Malpuech-Brugere C, Nowacki W, Gueux E, Kuryszko J, Rock E, Rayssiguier Y, Mazur A
Expression of miR-142-5p in peripheral blood mononuclear cells from renal transplant patients with chronic antibody-mediated rejection
There is no HPTA suppression, no receptor downregulation comparable to what you would observe with a hormone or secretagogue

1: behavioral data
