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doi: 10.1016/j.fertnstert.2011.03.030 79 WangJShenXXHuangXHZhaoZM

Global burden of cardiovascular diseases and risks, 1990-2022

Corneal injury repair One of the most clinically advanced applications of thymosin beta-4 concerns corneal wound healing

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CDK4 and CDK6 are important CDKs members that regulated the transition from G1 to S phase and bind to Cyclin Ds (D1, D2 and D3) to form CDK4/6-Cyclin complex after being activated by mitotic signals, while the over-activated CDK4/6 destabilizes the genome and chromosome, leading to uncontrolled proliferation and ultimately abnormal cell cycle regulation [44]

But consistent with other trials, neutralizing antibodies against ADI-PEG20 was observed in some patients in later part of treatment, leading to resistance [139]