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Mechanisms and management of antibiotic-associated diarrhea

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Preclinical studies demonstrated that AOD-9604 was generally safe after chronic oral application in rats and cynomolgus monkeys, with no genotoxic concerns identified

Yearly monitoring of B 12 status and suitable adjustment of the supplementation dose is recommended.50 For symptomatic deficiency (box 1) caused by insufficient dietary intake, intramuscular B 12 therapy is usually initiated with the aim of progressing to oral supplements once symptoms have resolved.789 Symptomatic deficiency in people with B 12 malabsorption Suggested treatment schemes differ considerably between countries