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With respect to energy generation, pyruvate, derived from carbohydrate oxidation, and fatty acids are imported into the mitochondria from the cytosol and converted to acetyl-CoA in the mitochondrial matrix through the actions of the PDHc and the enzymes of fatty acid oxidation

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Hepcidin suppresses brain iron accumulation by downregulating iron transport proteins in iron-overloaded rats

In conclusion, affecting the synthesis of ISC by inhibiting NFS1 and thus altering the sensitivity of cells to ferroptosis is a potential therapeutic tool to promote ferroptosis in lung cancer, but the precise mechanism remains to be further investigated
