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On the other side, long-term human safety data, standardized dosing protocols, and controlled efficacy trials remain extremely limited

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That's because most zinc is stored inside cells, and levels of zinc in the plasma or serum are influenced by factors unrelated to depletion, such as recent meals, time of day, muscle breakdown during weight loss, and inflammation

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This causes harmful chemicals to leach into their products during storage, and introduces dirt and bacteria into products between uses