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Consequently, prolonged use of pivalic acid-containing antibiotics, including pivampicillin, pivmecillinam, pivcephalexin, and cefditoren pivoxil (Spectracef), can lead to secondary L-carnitine deficiency (135)

Three trials that compared ALCAR treatment (1-3 g/day for 7-12 weeks) and antidepressant medications found ALCAR was as effective as antidepressants in treating depressive symptoms (95)

doi: 10.1111/j.1440-1681.2006.04336.x

Thus, L-carnitine may play a key role in maintaining liver function, by its effect on lipid metabolism

In a recent double-blind, randomized, placebo-controlled trial, the effect of ALCAR was examined in 229 participants treated for type 2 diabetes mellitus, hypertension, and dyslipidemia (46)

Several foods and nutrients, especially polyphenols like resveratrol, fiber-rich diets, and some probiotics, have been shown to limit TMAO production