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Arch Biochem Biophys 433:166175 Banerjee R, Zou CG (2005) Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein

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Therefore, in T1DM, because of the lack of portal insulin levels, the liver stops producing enough IGF-1, which is followed by a compensatory rise in GH levels