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EGF acts primarily on keratinocytes at the epidermal level

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The tested animals that were listed in the patent include rats, mice, rabbits, guinea pigs and pigs, as well as a single study in humans

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They are also supported by the finding that long-term administration of recombinant IGF-1 in humans with GH receptor deficiency is associated with decreased fat mass, increased lipolysis, and a faster rate of lipid oxidation (116)

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