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Primary mechanism: AOD-9604 works via beta-3 adrenergic receptor upregulation driving lipolysis

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MM is a hematological neoplastic disorder characterized by the accumulation of malignant plasma cells in the bone marrow, where the disease may cause complications that are often referred to as CRAB features (hyper-calcinemia, renal insufficiency, anemia and/or bone disease) or SLIM biomarkers (clonal bone marrow plasma cell percentage 60%

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This inhibition preserves nicotinamide availability for the NAD+ salvage pathway, the primary route for NAD+ regeneration in mammalian cells