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Biochem J 378(3):83949

As organisms age, the natural decline in plasma GHK-Cu levels correlates with diminished skin thickness, reduced collagen density, and impaired wound healing responses

Medline 18, R177R184

[DOI] [PubMed] [Google Scholar] [60].Boyle Y, Fernando D, Kurz H, Miller SR, Zucchetto M, Storey J, The effect of a combination of gabapentin and donepezil in an experimental pain model in healthy volunteers: Results of a randomized controlled trial, Pain 155(12) (2014) 25102516

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targeted therapy in RCC)by clarifying disease-specific regulatory mechanisms: PKD1 mutation-driven mitochondrial defects in ADPKD, DPP9-Nrf2-mediated sorafenib resistance in RCC, and PPARFABP1 axis dysregulation in IgA nephropathy, alongside shared core pathways (e.g., GPX4/SLC7A11 as central checkpoints)