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M., Activation of the CD95 (APO1/Fas) Pathway in Drug and GammaIrradiationInduced Apoptosis of Brain Tumor Cells, Cell Death and Differentiation 5, no

It represents more than 80% of all cases

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However, SASP is also essential for remodeling and promoting wound healing, which requires a strict control of the inflammatory response, thus avoiding the induction of cell aging phenotypes that contribute to the development of chronic inflammatory diseases (233)

Disruption of protein homeostasis is recognized as a hallmark of aging [70], and previous studies have shown that impaired ovarian angiogenesis and vascular remodeling contribute to inadequate follicular development and ovarian aging [71]